A number of experts warned that Dr Karina F Moegni, SpBP, should not be too quick in claiming that the aaPRP (autologous activated platelet-rich plasma) he developed could provide benefits for COVID-19 patients. The reason is, this therapy has not passed phase 3 clinical trials so its efficacy against Corona virus infection is not yet known.
A similar opinion was also conveyed by molecular biologist Ahmad Rusdan Utomo. He said, it was better if Dr. Karina gave a clear clarification regarding her findings by conducting a phase 3 clinical trial first.
Previously, Dahlan Iskan appreciated the findings of aaPRP therapy developed by plastic surgeon Dr Karina. This therapy utilizes a protein in a person’s platelets or red blood cell fragments as an anti-inflammatory.
Experts from a number of medical disciplines have warned Dr. Karina not to rush to publish therapies whose benefits have not been proven through scientific trials.
What is Platelet-rich plasma (PRP)
Platelet-rich plasma (PRP) is a product produced from fresh whole blood containing platelets in high concentrations above normal, with anti-inflammatory and pro-regenerative properties so that the body is able to repair tissues more efficiently. PRP works by stimulating faster wound healing, initiating wound repair by releasing locally acting growth factors via degranulation of -granules. PRP exhibit antimicrobial activity and are not mutagenic.
How Platelet-rich plasma (PRP) Produce
The centrifugation method is the basis for produce PRP, resulting in a volume of about 10 percent of the total blood drawn
Activated phrase because after stored this cell must be active before get it benefit. The most commonly used platelet activation method is adding calcium chloride (CaCl2) and thrombin into PRP to form a gel preparation, In addition, adenosine diphosphate (ADP) can also be used. Thrombin activates platelets directly when ions calcium replenishes bound by anticoagulants ACD-A.
Platelet rich plasma can be given as fibrin glue or as a hemostatic agent. PRP liquid can be directly applied to the wound surface, applied after the dermaroller while being massaged, or as a filler in the form of liquid or gel that is injected into the dermis part of the skin.